Cancer and Modified Citrus Pectin

Modified citrus pectin is currently a source of much interest among cancer researchers. It has demonstrated its usefulness in helping prevent cancers from spreading (metastasizing) as well as helping to kill existing cancer cells.

oranges photo

Photo by jenandtomh

Citrus pectin comes from the pulp and peals of various citrus fruits like oranges, grapefruits, lemons and tangerines. It is a complex polysaccharide composed of long chains of sugar carbohydrates. In it’s long chain form it is practically indigestible and functions as fiber. Citrus pectin is “modified” by chemicals or heat to produce shorter chain molecules that dissolve much better in water and more easily enter the blood stream through the digestive tract.

How Modified Citrus Pectin Prevents Cancer From Spreading

Cancer cells, like all cells in your body, divide and reproduce themselves. In normal cells the “mother” cell then dies (undergoes apoptosis) and the new “daughter” cell continues its function. For cancer cells, the division is often more rapid and the mother cells do not die or undergo apoptosis, so the tumor or mass of cancer cells grows.

Some of the cancer cells may detach or free themselves from the main tumor mass and enter the blood stream (intravasation). When these cancer cells reach the surface of an organ (endothelium) they adhere or stick to the surface. Other free cancer cells may also adhere or clump together at sites on various organs.

These “micro-tumors” or micrometastases become supplied with nutrients when new blood vessels grow to these cancer cells. This new colony of cancer cells begins to grow and we say a secondary tumor has formed and the cancer has spread or metastasized.

Now, at each step of this metastasizing process the cancer cells need some help. Galactoside­binding lectin, or Galectin-3 (or even shorter, Gal-3) is a carbohydrate-binding lectin that helps protect cancer cells from normal cell death or apoptosis.

When cancer cells become detached from the main tumor they experience a lost of anchorage (anoikis) and should undergo apoptosis. Galectin-3, however, helps prevent cell death when they lose their anchorage.

Galectin-3 also helps cancer cells adhere to the endothelium or cell walls of various organs. Galectin-3 further helps newly arriving cancer cells adhere to existing cancer cells so they form a clump.

Galectin-3 then exhibits “angiogenic activity” that helps grow new blood vessels to this clump of cancer cells, helping them survive and prosper.

Studies involving colon, stomach and thyroid cancer indicate that the amount of galectin-3 increased as the cancer tumors grew. This increase in the amount of galectin-3 helps cancer cells spread to other sites in the body.

Modified citrus pectin interferes with galectin-3 every step of the way.

Modified citrus pectin helps reduce galectin-3’s “anti-anoikis effect” and so helps promote cell death when the cancer cells become detached from the main tumor mass.

Modified citrus pectin has “anti-adhesive properties” and helps prevent cancer cells from attaching to the endothelium of organs. It also helps prevent newly arriving cancer cells from attaching or clumping together.

Modified citrus pectin also helps inhibit galectin-3’s angiogenic activity so new cancer colonies do not receive nourishment from new blood vessels.

This interference with galectin-3 is one reason modified citrus pectin is so important.

What Do Clinical Studies Show About Modified Citrus Pectin?

Prostate cancer is a common problem and one of the top causes of cancer deaths in American men.

A number of clinical trial examined the PSA doubling time for men with prostrate cancer. As the cancer grows the levels of PSA (prostate-specific antigen) in the blood increase. Slowing the rate of PSA increase, without other interventions, means prolonging the symptom-free life of the patient. So, these are important studies.

One clinical study of patients with prostrate cancer was conducted to determine the doubling time of PSA. While PSA is present in all men with healthy prostrates, it is usually elevated in men with prostrate cancer. As the cancer progresses the level of PSA increases. The time it takes for the PSA level to double is a good indicator of how quickly the cancer is growing.

The men in this study were given PectaSol from EcoNugenics, a form of modified citrus pectin often used in clinical trials. The dose was 15 grams of PectaSol per day in three divided doses.

The patients were seen at least once a month and PSA doubling times were evaluated every 3 months.

The results of this study showed the PSA doubling time increased from a low of 5.7% to a high of 193.3% with the majority of patients experiencing at least a 30% increase in doubling time. This study concluded that “Modified Citrus Pectin appears to slow the PSA doubling time in prostate cancer patients with low levels of PSA.”

Another clinical trial of PSA doubling time monitored patients before and after starting the modified citrus pectin supplementation. Each patient had early, untreated prostrate cancer confirmed by a biopsy. PSA levels were rising in all participants.

At the start of supplementation phase, patients were given PectaSol modified citrus pectin capsules. They each took 14.4g per day in three divided doses with 8 ounces of juice or water.

Here is one graph showing how the progress of PSA has been slowed after starting modified citrus pectin supplementation.

In this study 70% of the participants showed significantly slower PSA increases. This indicates that the primary tumor growth has been slowed by the pectin.

A study involving mice was conducted to examine the effects of various concentrations of modified citrus pectin in drinking water. The mice were injected with cancer cells, then provided with water with 0%, 1.0%, 2.5% and 5.0% modified citrus pectin.

The of number of liver metastases found for these groups at the end of the trial was 6, 4, 3, and 3. There were significantly fewer sites of cancer in the mice drinking the higher concentration of modified citrus pectin.

In addition, the main spleen tumor’s size (in cubic centimeters) for these groups was 1.71, 1.28, 0.90 and 0.76. Again, the tumors were significantly smaller in the mice drinking the higher concentrations of modified citrus pectin.

Clinical studies show modified citrus pectin does more than merely retard the progress of cancer. It can help kill off cancer cells in the main tumor.

In one study investigated the effects of [popup_product]PectaSol[/popup_product] and PectaSol-C modified citrus pectins on prostate cancer cells. This was done in the laboratory rather than on actual patients. But, it shows how toxic modified citrus pectin can be on human cancer cells.

Here, two types of cancer cells were used with varying concentrations of modified citrus pectins, PectaSol and PectaSol-C, applied to the medium containing the cancer cells. The graph shows the percents of cancer cells killed (undergoing apoptosis) by the application of the pectin solutions.

The authors conclude that the tested modified citrus pectin solutions reduce cell viability” and can “induce cell growth inhibition and apoptosis.”

Cancer CURE Modified Citrus Pectin

Dr. Kevin Conners talks about modified citrus pectin being a Galectin-3 blocker and how this affects cancer.

Conclusions You Can Use

Modified citrus pectin is useful is reducing the growth and spread of a variety of cancers.

If you have been diagnosed with cancer, it would probably be wise to supplement with modified citrus pectin to help any cancer treatments you may receive to be more effective.

Buy Modified Citrus Pectin

References

Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells as published in PLOS One

Modified citrus pectin anti-metastatic properties: one bullet, multiple targets as published in Carbohydrate Research

Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model as published in the World Journal of Gastroenterology

Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure as published in Glycobiology

PectaSol-C Modified Citrus Pectin Induces Apoptosis and Inhibition of Proliferation in Human and Mouse Androgen-Dependent and – Independent Prostate Cancer Cells as published in Integrative Cancer Therapies

MODIFIED CITRUS PECTIN SLOWS PSA DOUBLING TIME: A Pilot Clinical Trial as Presented at the International Conference on Diet and Prevention of Cancer

Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study as published in Prostate Cancer and Prostatic Diseases

THE ROLE OF MODIFIED CITRUS PECTIN AS AN EFFECTIVE CHELATOR OF LEAD IN CHILDREN HOSPITALIZED WITH TOXIC LEAD LEVELS as published in Alternative Therapies in Health and Medicine

2 thoughts on “Cancer and Modified Citrus Pectin

    1. HealthyBodySupport Post author

      Citrus pectin consists of very long chains of sugar molecules. This makes it hard to digest (break down). It’s good for fiber, though. It does not readily pass into the blood stream. So, eating more fruit will not help to remove heavy metals.

      Modified citrus pectin is citrus pectin that has been broken into shorter chains that more easily gets into your blood stream. This allows it to get to the cells to “claw” at and grab the heavy metals to remove them.

      So, you have to buy it as a supplement.

      Reply

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