Tag Archives: clinical trials

Brain Boosting Bacopa Monnieri – What Science Says About Bacopa

Bacopa monnieri is traditional Ayurvedic medicinal herb grown in India. It has been widely touted as a brain booster with other positive effects such as reduction of anxiety. Often called water hyssop, it is a popular plant used in aquariums.

The herb contains many active components including alkaloids and saponins (that form a soapy froth when shaken in a water solution). Most people recognize the saponins Bacosides A and B as the most significant components.

Bacopa monnieri is marketed by many supplement manufacturers which use a variety of phrases to describe its effects. Some of these marketing slogans include:

  • Optimize your brain power
  • Supports memory enhancement & learning
  • Supports memory, enhances mental performance
  • Brain & memory support
  • Mental focus
  • Support cognitive function and brain health
  • Mental alertness
  • Excellent rejuvenative for the mind
  • Benefits congnitive functions

These claims make it seem like you should start taking bacopa monnieri before your next algebra test or your final exams to make sure you get a high grade. After all, you want every advantage possible to succeed in life.

But, what do the scientific studies show about the benefits of bacopa monnieri? Are these marketing slogans simply hype that over-promise what you can really expect?

Scientific Studies of Bacopa Monnieri

Human scientific studies of bacopa monnieri almost always provide subjects with enough capsules to last 12 weeks. It seems to take 12 weeks, 3 months, for bacopa to show an effect. Some studies last longer to see the residual effects.

The dose used is normally that recommended by the Central Drug Research Institute (CDRI), a premier drug research institute of India. This dose is often 300 mg for persons under 90 kg (190 pounds), and 450 mg for persons over 90 kg. This is equivalent to 6g and 9g of dried rhizome.

Most double-blind placebo-controlled studies work with 50 to 100 test subjects. These studies are not conducted by large pharmaceutical manufactures who can afford to run trials with thousands of subjects. This herb is not going to generate billions of dollars of profit for the pharmaceutical industry.

The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects is a study that was reported in the journal Psychopharmacology.

Forty-six healthy volunteers (11 males and 35 females) were recruited for the study. There were randomly dividied into two groups, one taking B. monniera (300 mg) daily and the other group taking an identical looking placebo.

All members of the trial underwent an initial 30 minute test of memory skills. They were then given the bottles of capsules there were to take for 12 weeks. The subjects were tested again after 5 weeks and after 12 weeks.

These tests were standard tests of “attention, short-term memory, verbal learning, memory consolidation, executive processes, planning and problem solving, information processing speed, motor responsiveness, and decision making.”

There were no significant differences between the groups after 5 weeks. But, after 122 weeks, the group taking bacopa monnieri showed significant positive effects in the follow areas:

  • Improved speed of visual information processing
  • Learning rate
  • Memory consolidation
  • Decrease in forgetting rate
  • Decrease in anxiety

The reseachers concluded that “the current finding suggests that B. monniera may improve higher order cognitive processes that are critically dependent on the input of information from our environment such as learning and memory.”

Another study was reported in the article Chronic Effects of Brahmi (Bacopa monnieri) on Human Memory which was published in the journal Neuropsychopharmacology.

This study was a double-blind, randomized, placebo controlled study. The study began with 84 healthy volunteers, of which 76 adults, 28 males and 48 females, between 40 and 65 years of age completed the study. These volunteers were tested for an hour on various memory functions prior to the trial, after the 3 month trial, and again 6 weeks later.

At the end of the 3 month trial period the Bacopa group showed significantly better performance on delayed recall of word pairs over the placebo group. The testing 6 weeks after the trial showed no significant differences between the groups.

The reseachers conclude that “the effect appears to be a reduction in the amount of information lost from memory.”

Another study investigated the Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial and was published in the Journal of Alternative and Complementary Medicine.

This two-group randomized, placebo-controlled, double-blind trial study recruited 54 participants aged 65 and older who lived independently with no signs of dementia. Forty-eight volunteers completed the study, with 24 participants in the Bacopa and plecabo groups. The Bacopa group took 300 mg per day of B. monnieri extract while the placebo group took a similar looking capsule. The Bacopa tablet contained the equivalent of about 15 g of herb and 150 mg of the bascosides A nad B.

The primary interest was in delayed recall of verbal information. Other tests were also included such as the Stroop task of recognized incongruous stimuli (such as recognizing the word green when it is printed in red).

The intervention (trial) involved 12 weeks of taking the B. monnieri or placebo.

The group taking Bacopa showed significantly improvement in the memory recall task and shortened reaction times in the Stroop test compared to the placebo group. In addition, the Bacopa group showed a decrease in depression and anxiety compared to the placebo group.

The researchers concluded that “this study provides further evidence that standardized extracts of B. monnieri have potential for safely enhancing cognitive performance in aging.”

Conclusions

Bacopa Monnieri: Amazing And Proven Herb For Memory

In this video Dr Meschino explains how bacopa monnieri is proven to improve memory in various types of memory-challenged patient studies. For more information from Dr Meschino Click Here.

Research studies show bacopa monnieri has positive effects on short term memory retention. Other benefits include recognizing information when presented in new or novel ways (incongruous information) and reduces depression and anxiety. These effects typically take 12 weeks to become apparent.

With our current aging population wanting to clear up “fogginess” as well as young people looking to have a sharper mind, boosting brain function is a highly desired goal. The excelling reviews for Brain Boost have shown that this multi-ingredient product has positive effects for many people.

Take a look at it yourself to see if you could benefit from it.

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Stem Cell Therapy Can Help You

Stem cells from your own body’s fat cells can be extracted, concentrated and reintroduced into your body. They help your body heal joint arthritis, repair heart damage, restore function to stroke victims, and much more.

What Are Stem Cells?

Stem cells are undifferentiated cells than can produce (differentiate) cells of a specific or specialized type. Stem cells divide and produce new differentiated cells throughout your life. For example, as cell damage occurs (as in a cut), new skin cells are produced by stem cells to repair the cut.

Stem cells circulating in your blood can reach any organ that needs repair. The stem cells at that organ can produce exactly the kinds of cells needed to repair the organ so it functions normally again. The more stem cells in circulation, the faster the healing process occurs.

Everyone has stem cells. Because cells normally die off, stem cells are required for life. Some experts say we could live only a few hours if we had no stem cells.

Adult stem cells from your own body can be harvested from many sources. Most popular sources of stem cells are your bone marrow or your fat or adipose tissue through liposuction. The adipose tissue is processed in a way that separates the fat from the stem cells. The stem cells are them be injected in areas of the body that require repair.

Adult Stem Cell Therapy for Rheumatoid Arthritis and Osteoarthritis – Neil Riordan, PhD

Photo by handarmdoc

Dr. Riordan discusses focuses on mesenchymal stem cells harvested from fat tissue and the role they play in reducing inflammation, repairing tissue and modulating the immune system.

Stem Cells: Current Clinical Trials and Beyond

There are currently over 2,000 studies that are actively investigating stem cells or recruiting people to participate in a clinical trial involving stem cells. As of this writing, several of these studies are:

Results of stem cell trials have shown that injections have helped regrow cartilage, reducing or eliminating joint discomfort. Stem cells have helped restore corneas, repair heart damage, treat stroke victims, and even show promise in helping repair spinal cord injuries. Stem cells have helped diabetic patients restore circulation in their legs to avoid amputation.

As you can imagine, many studies are first done on animals to see if a certain treatment is effective. Those treatments that are effective can then be using in human trials.

One study, Stem cell therapy in a caprine model of osteoarthritis, investigating the usefulness of stem cells for regeneration of the medial meniscus or fibrocartilage in the joints of goats. Adult goat stem cells were introduced into the joints. The study noted “marked regeneration” of the meniscus. Repair tissue was noted after 6 weeks, and after 20 weeks further repair tissue was noted in 7 of 9 joints treated. The reseachers concluded that, “This study suggests that there may be a therapeutic benefit associated with intraarticular injection of stem cells following traumatic injury to the knee.”

Stem Cells: Results of Applications in Humans

Knee arthritis two years after stem cell therapy by Harry Adelson, N.D.

Carrie describes her outcome two years after stem cell therapy for her painful, arthritic knees by Harry Adelson, N.D.

Stem Cell Treatment For Knees: Mycal’s Story

Mycal was in constant pain which was impairing his function and quality of life. He wanted to avoid invasive knee replacement therapy. He chose adult stem cell therapy and watch him now tackle his game pain free! Stem Cell therapy for joint injuries are an ideal choice for those looking to avoid invasive surgery and prolonged downtime.

Enhance Your Stem Cells

You can receive stem cells in your joints or an intravenously for a whole body infusion in many clinics throughout the United States. Typically, the clinic will use fat cells taken, via liposuction, from your own body. The fat cells are placed in a centrifuge where the stem cells can be concentrated and extracted. The cells are then introduced into your body where they begin their work.

All this takes just a couple of hours. You’ll experience no “down time” and can go about your daily activities after the injections.

At this time, the cost of this procedure is approximately $4000 for one area ( for example, a knee or a shoulder) and $6000 for two areas (both knees or both shoulders). Insurance does not currently cover this procedure so you will have to pay for it yourself.

Stem Cell Enhancing Supplements

Because the cost such procedures more than many people can afford, some people are turning to supplements than can enhance stem cell production or mobilization. One such product is shown below. Investigate it and use it if you think it could help you.

AIDAN Products Stem-Kine 60 capsules

  • Double the number of circulating stem cells for an extended period of time.
  • stimulate your body's ability to mobilize your own stem cells
All natural ingredients, all on the FDA's generally regarded as safe list. No reported adverse side effects. Made in Chandler, AZ USA in a GMP certified manufacturing facility.

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