Tag Archives: Diabetes

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Obesity, Diabetes and Moringa Oleifera

Because of the increasing prevalence of obesity and diabetes, many are looking to more natural ways to control blood sugar and help reduce weight. And this search includes Moringa Oleifera, used for thousands of years for just these purposes.

Moringa oleifera is a fast-growing, small, drought-resistant tree. It’s native to the sub-Himalayan areas around north-west India and has spread to tropical and sub-tropical areas of Africa, Arabia, South East Asia as well as the Pacific and Caribbean islands and on into South America.

Ancient cultures have found that over 20,000 plants have shown to have medicinal effects. And people have found that practically the entire Moringa oleifera tree is useful for medicinal purposes. This includes its fruit, seeds, flowers, leaves, bark and roots. Modern research has identified many essential nutrients including vitamins, minerals, amino acids, antioxidants, anti-inflammatory agents as well as omega 3 and omega 6 fatty acids.

From Health Benefits of Moringa Oleifera published in the Asian Pacific Journal of Cancer Prevention

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Does Carbohydrate Restriction Fight Cancer? Use the Warburg Effect to Fight Cancer

Have we known that carbohydrate restriction fights cancer for nearly 100 years? One of the defining characteristics of cancer cells is the inefficient metabolism of glucose to lactate even in the presence of oxygen. This aerobic glycloysis (the breakdown of glucose by enzymes without oxygen) is known as the Warburg effect and has been known since the 1920s. Yet, little has been done to utilize this fact in helping to prevent or treat cancer.

The National Cancer Institute predicts that “in 2018, an estimated 1,735,350 new cases of cancer will be diagnosed in the United States and 609,640 people will die from the disease.”

In spite of all the cancer research, the number of people getting cancer in on the increase.

New Cancers in the United States

Shouldn’t we limit the primary nutrient of cancer cells as a means of fighting cancer?

Sugar is a Key Nutrient for Cancer Cells

Your body typically processes glucose (a sugar from carbohydrates) in two ways. Each way produces ATP molecules (adenosine 5′-triphosphate, the energy source for all cells of the body). Continue reading

Berberine – Scientific Review on Benefits, Usage, Dosage

Berberine is an active compound from Huang Lian, Rhizoma Coptidis, that has been used for thousands of years in Chinese medicine to treat bacterial diarrhea and diabetes. Numerous research studies have found many benefits of berberine.

These benefits include general antioxidant and anti-inflammatory effects as well as specific effects such as:

diabetic photo

Photo by Richard Elzey

  • Antidiabetic effects
    • Glucose-lowering effect
    • Significantly increased glucose disposal rate
  • Antihyperlipidemic (treats high levels of fats (lipids), such as cholesterol, in the blood)
    • Decreases cholesterol
    • Decreases triglycerides
    • Decreases LDL-c
  • Cardiovascular effects
    • Reduces arrhythma
    • Lowers blood pressure

Berberine and Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease is characterized by excess fat in the liver due to causes other than excessive alcohol use. This is closely related to insulin resistance and the metabolic syndrome. Insulin sensitizer drugs such as metformin and thiazolidinediones (such as pioglitazone) are often prescribed.

One 16 week study involved 184 subjects who were randomly assigned to three groups:

  • 62 lifestyle intervention
  • 60 lifestyle intervention and pioglitazone (15 mg per day)
  • 62 lifestyle intervention and berberine (500 mg three times a day)

This study showed that the subjects using lifestyle intervention and berberine lost significantly more weight, lowered their BMI significantly more, and reduced their waist circumference significantly more than the other two groups.

Lipid profiles and liver enzymes in the group using lifestyle intervention and berberine also improved more than the other two groups.

Berberine and Type 2 Diabetes

In one study three month long study, 110 patients with type 2 diabetes completed the study. They were randomized into groups taking berberine (500 mg twice a day) or a placebo.

The study wanted to determine the effects of berberine on fasting glucose levels, the 2 hour blood glucose levels during an oral glucose tolerance test, triglycerides, HDL-c, LDL-c, HbA1c levels, and the glucose disposal rate. Also of interest were the changes in BMI and blood pressure.

As in other clinical trials, subjects receiving berberine showed significant improvements over those taking a placebo. In particular, significant improvements were seen in both the fasting blood glucose levels as well as the 2 hour oral glucose tolerance test levels. Also significantly better were many blood components including HbA1c, a 35.9% reduction of triglycerides, an 18% reduction in total cholesterol, and a 21% reduction of LDL-c levels.

In fact, the reduction of HbA1c were similar to the reduction seen in existing prescription drugs used to treat type 2 diabetes.

Significantly more body weight was lost in the berberine group resulting in a greater reduction in BMI. And a significant drop in both systolic and diastolic blood pressures were observed.

The weight loss, though significant, was not thought sufficient to bring about the broad scope of improvements demonstrated in the study. Something else is playing a role.

Berberine and Metformin for Type 2 Diabetes Treatment

One study involved 84 subjects (49 women and 35 men) from an outpatient clinic with type 2 diabetes. The main purpose of the study was to determine the effects of berberine on glycemic control as measured by HbA1c levels. Also of interest were fasting blood glucose levels, after meal blood glucose levels, triglycerides, total cholesterol. HDL-c and LDL-c levels.

36 of these patients who were recently diagnosed with type 2 diabetes were assigned to study A. This involved a two month period during which the patients modified their diet. After that the patients were randomly assigned to take either berberine or metformin for 13 weeks.

During the 13 week trial, half the subjects in group A were assigned to take 500 mg of berberine three times a day prior to eating and the other half took 500 mg of metformin three times daily after meals.

The remaining 48 type 2 diabetes patients were not being helped by diet modification and drug therapy using sulfonylureas, metformin, acarbose or by using insulin alone were assigned to study B.

The unrespponsive patients in study B were assigned to take 500 mg of berberine three times daily in addition to their regular medication for a period of 3 months.

Results

Both berberine and metformin had significant effects in lowering blood glucose including HbAc1, fasting blood glucose and post meal blood glucose in study A. Berberine, however, showed better lipid controlling activity than metformin. Triglycerides and total cholesterol were significantly lower in the berberine group compared to the metformin group.

In study B where berberine was added to the existing medication, berberine produced significant results within the first 7 days. Both fasting blood glucose and after meal blood glucose were significantly lowered.

After 5 weeks HbAc1 levels were significantly lower. Fasting blood glucose and after meal blood glucose levels continued to decline. Blood lipids including triglycerides, total cholesterol and LDL-c were significantly lowered. Also waist and the waist to hip ratio registered a significant drop.

Berberine and Gut Bacteria

Since the Chinese have been using berberine for thousands of years to treat bacterial diarrhea, we need to understand more about how it berberine affects bacteria in the gut.

One study is particularly revealing in this area. A group of 187 patients were included in the final results of a study to help treat type 2 diabetes. The study tested a Chinese formula containing Gegen (Radix Puerariae), Huangqin (Radix Scutellariae), Huang Lian (Rhizoma Coptidis from which we get the active ingredient berberine) and Gan Cao (a honey-fried Licorice Root Radix Glycyrrhizae).

Patients were give this formula in high, moderate or low dose, or a placebo for 12 weeks. The formula provided clinically meaningful and dose-dependent reductions in fasting blood glucose and HbA1c (a measure of average plasma glucose concentration). The high dose of this formula also significantly improved HOMA-β (a measure of insulin resistance).

Equally as important, the study showed the formula modified the gut microbiome in a dose dependent manner. Significant improvements were observed in the gut biome, enriching the number of beneficial bacteria. And, this change in the gut microbiome took place before improvement of the type 2 diabetes symptoms.

This indicates that the change in the gut microbiome was not a consequence of symptom relief. Rather, it appears that the improvement of the gut microbiome contributed to the improvement of glucose regulation in type 2 diabetes patients. The idea is that the change in the gut microbiome, rather than the herbal formula, was the cause of the relief of the type 2 diabetes symptoms.

Berberine and Your Health

Berberine has been used for thousands of years. It’s healthy benefits are widely known and have been scientifically investigated and proven.

It has an effect of the gut microbiome that enhances health-giving organisms that help regulate a number of systems including lipid (fat) metabolism, the cardiovascular system, and provide help in treating diabetes that seems equal that of modern drugs.

Your gut microbiome is often called your second brain or the forgotten organ. Read more about your gut biome at Can You Lose Weight and End Obesity by Managing Your Gut Microbiome?

References

Stem Cell Therapy Can Help You

Stem cells from your own body’s fat cells can be extracted, concentrated and reintroduced into your body. They help your body heal joint arthritis, repair heart damage, restore function to stroke victims, and much more.

What Are Stem Cells?

Stem cells are undifferentiated cells than can produce (differentiate) cells of a specific or specialized type. Stem cells divide and produce new differentiated cells throughout your life. For example, as cell damage occurs (as in a cut), new skin cells are produced by stem cells to repair the cut.

Stem cells circulating in your blood can reach any organ that needs repair. The stem cells at that organ can produce exactly the kinds of cells needed to repair the organ so it functions normally again. The more stem cells in circulation, the faster the healing process occurs.

Everyone has stem cells. Because cells normally die off, stem cells are required for life. Some experts say we could live only a few hours if we had no stem cells.

Adult stem cells from your own body can be harvested from many sources. Most popular sources of stem cells are your bone marrow or your fat or adipose tissue through liposuction. The adipose tissue is processed in a way that separates the fat from the stem cells. The stem cells are them be injected in areas of the body that require repair.

Adult Stem Cell Therapy for Rheumatoid Arthritis and Osteoarthritis – Neil Riordan, PhD

Photo by handarmdoc

Dr. Riordan discusses focuses on mesenchymal stem cells harvested from fat tissue and the role they play in reducing inflammation, repairing tissue and modulating the immune system.

Stem Cells: Current Clinical Trials and Beyond

There are currently over 2,000 studies that are actively investigating stem cells or recruiting people to participate in a clinical trial involving stem cells. As of this writing, several of these studies are:

Results of stem cell trials have shown that injections have helped regrow cartilage, reducing or eliminating joint discomfort. Stem cells have helped restore corneas, repair heart damage, treat stroke victims, and even show promise in helping repair spinal cord injuries. Stem cells have helped diabetic patients restore circulation in their legs to avoid amputation.

As you can imagine, many studies are first done on animals to see if a certain treatment is effective. Those treatments that are effective can then be using in human trials.

One study, Stem cell therapy in a caprine model of osteoarthritis, investigating the usefulness of stem cells for regeneration of the medial meniscus or fibrocartilage in the joints of goats. Adult goat stem cells were introduced into the joints. The study noted “marked regeneration” of the meniscus. Repair tissue was noted after 6 weeks, and after 20 weeks further repair tissue was noted in 7 of 9 joints treated. The reseachers concluded that, “This study suggests that there may be a therapeutic benefit associated with intraarticular injection of stem cells following traumatic injury to the knee.”

Stem Cells: Results of Applications in Humans

Knee arthritis two years after stem cell therapy by Harry Adelson, N.D.

Carrie describes her outcome two years after stem cell therapy for her painful, arthritic knees by Harry Adelson, N.D.

Stem Cell Treatment For Knees: Mycal’s Story

Mycal was in constant pain which was impairing his function and quality of life. He wanted to avoid invasive knee replacement therapy. He chose adult stem cell therapy and watch him now tackle his game pain free! Stem Cell therapy for joint injuries are an ideal choice for those looking to avoid invasive surgery and prolonged downtime.

Enhance Your Stem Cells

You can receive stem cells in your joints or an intravenously for a whole body infusion in many clinics throughout the United States. Typically, the clinic will use fat cells taken, via liposuction, from your own body. The fat cells are placed in a centrifuge where the stem cells can be concentrated and extracted. The cells are then introduced into your body where they begin their work.

All this takes just a couple of hours. You’ll experience no “down time” and can go about your daily activities after the injections.

At this time, the cost of this procedure is approximately $4000 for one area ( for example, a knee or a shoulder) and $6000 for two areas (both knees or both shoulders). Insurance does not currently cover this procedure so you will have to pay for it yourself.

Stem Cell Enhancing Supplements

Because the cost such procedures more than many people can afford, some people are turning to supplements than can enhance stem cell production or mobilization. One such product is shown below. Investigate it and use it if you think it could help you.