Tag Archives: overweight

Forskolin for Weight Loss: What Science Says

Forskolin: You’ve heard about it from Dr. Oz and many other sources. But, has it been proven effective? And, if so, what dose is required to make fat loss happen?

Preliminary Study of Forskolin

An early human study of Forskolin described in the journal article A Coleus forskohlii extract improves body composition in healthy volunteers: An open-label trial) involved 15 healthy volunteers. The study lasted 8 weeks. Each volunteer took 500 mg of 10% forskolin extract twice a day which their meals.

Of the 15 initial volunteers, 12 completed the study. After 8 weeks, statistically significant reductions were noted in body mass index (BMI), body weight, fat content, lean body mass and basal metabolic rate.

On average, the volunteers went from 146 pounds to 141 pounds, a loss of 5 pounds. Average BMI decreased from 24.92 to 23.99. Body fat went from 65.3 pounds to 61.2 pounds.

This was a preliminary study of forskolin. Further double-blind placebo controlled studies were needed to confirm the effectiveness of forslolin for weight loss.

Men’s Forskolin Study

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A study, Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men, reported in the journal Obesity involved 30 men. This study was conducted by the University of Kansas, Department of Health, Sport and Exercise Sciences, Applied Physiology Laboratory.

Fifteen randomly chosen men were assigned to take forskolin supplements (250 mg of 10% forskolin extract twice a day) for 12 weeks. The other 15 men were provided with a placebo. All of these men were overweight or obese with a BMI greater than 26 who were sedentary, non-active individuals who did not have asthma, low blood pressure or gastric ulcers.

The results shows that forskolin produced statistically significant changes.

The body fat percentage decreased for the forskolin group from 35.17% to 31.03%. The placebo group showed no significant difference in body fat percentage.

The fat mass of the forskolin group dropped a significant amount from 82.5 pounds to 72.5 pounds. The placebo group had no significant change is fat mass.

The researchers concluded that “forskolin promotes favorable changes in body composition by significantly decreasing percentage body fat and fat mass and increasing bone mass.” They believed that forskolin worked to activate free fatty acid release from the fat cells, making fat more available for the production of energy in the body–thus “burning” more fat.

Disappointing Women’s Study of Forskolin?

Another double blind placebo control study, Effects of Coleus Forskohlin Supplementation on Body Composition and Hematological Profiles in Mildly Overweight Women, was reported in the Journal of the International Society of Sports Nutritio. This study was performed on 19 overweight females (BMI between 25 and 35) who completed the 12 week study.

Each member of the study took two capsules each day. Seven members received capsules containing 250 mg of 10% forskolin extract while 12 members received a similar placebo. They took one capsule in the morning and one in the evening a half hour before mealtime.

The results of this study did not show statistically significant differences between the forskolin group and the placebo group. But, it should be noted that the number of participants was smaller than the men’s study, so to be statistically significant any differences needed to be large.

The actual results of this study, though not “statistically significant”, are still important to note.

The average body weight for the forskolin group decreased from 192.2 pounds to 190.9 pounds while the average body weight for the placebo group increased from 189.8 pounds to 192.7 pounds.

The average fat mass for the forskolin group decreased slightly from 74.56 pounds to 74.1 pounds while the average fat mass for the placebo group increased from 68.93 pounds to 71.34 pounds.

These changes for the forskolin group are in a healthful direction, while the changes for the placebo group tended to be unhealthy. For most people, these results would be seen as a victory!

While this study did not show statistically significant results, the results point in the right direction.

Is Forskolin a Miracle Herb?

Dr. Oz calls forskolin “lightening in a bottle.” But, he exaggerates everything to make a point, and often to make a profit.

An article, Forskolin: A Successful Therapeutic Phytomolecule, in the East and Central African Journal of Pharmaceutical Science describes some of the uses of forskolin. Among them are:

  • Cardiovascular disease: Forskolin has been shown to lower blood pressure by relaxing the vascular smooth muscles. It helps increase oxygen consumption and increases blood flow in the brain and could help in stroke recovery.
  • Asthma and allergies: Dry forskolin powder in aerosol form helps bronchodilation improving breathing.
  • Psoriasis: The ability of forskolin to regulate cAMP levels benefits sufferers of psoriasis.
  • Glaucoma and Increased Intraocular Pressure: Some studies have shown forskolin to reduce pressure inside the eye, or intraocular pressure of glaucoma.
  • Depresion: Animal studies show forskolin may act as an antidepressant.
  • Hypothyroidism: Forskolin has has shown to increase thyroid hormone production and stimulate thyroid hormone release.
  • Cancer: Forskolin has been shown to reduced tumor colonization (melanoma) in the lungs by 70%.
  • Weight Loss: Several studies in humans have shown that forskolin can induce weight loss or help prevent weight gain.
  • Digestion: Forskolin studies indicate it stimulate digestive secretions including hydrochloric acid, pepsin, amylase, and pancreatic enzymes.

Forskolin seems to have many positive effects on the human body, including weight loss.

For those struggling to lose weight, forskolin may be the answer.

Forskolin works to activate free fatty acid release from the fat cells so fat can be burned. You  can burn fat even faster with 7 Keto DHEA which increases thermogenic activity within your body. This could be the combination that gives you success in your fat loss efforts.

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Time Restricted Eating in Humans Has Anti-Aging and Anti-Obesity Effects

Would you believe that by limiting the number of hours in a day that you eat you could lose weight, slow the aging process, improve insulin sensitivity, and lower your risks for cardiovascular disease, diabetes and cancer?

That’s exactly what modern research is telling us.

clock photo

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The journal Cell in an article entitled Promoting Health and Longevity through Diet: From Model Organisms to Humans tells us that limiting daily food intake to a 5 to 7 hr time window while consuming the normal number of calories can improve health when compared with a standard three to five meals per day.

Another journal, Cell Metabolism, presents the article Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges. It describes experiments done on mice, which are near enough to humans to tell us what will be effective for us.

The experimenters tested various conditions including time restricted feeding (with 8-9 hours food access) seven days a week, and time restricted feeding only five days a week. Time restrictions only 5 days a week is of particular interest because it reflects a more relaxed feeding schedule we normally use on the weekends.

They tested diets that were high in fat, and diets that were high in both fat and fructose. You probably know that fructose is particularly important since it is being added to almost all manufactured and processed foods found in the grocery store. Consuming a high fructose diet can cause glucose intolerance and fatty liver disease.

They found that the benefits of time restricted feeding were proportion to the fasting duration. That is, the longer the mice went each day without food, the more healthy the mice become. So even though they consumed the same number of calories, the duration of the fasting interval were the controlling factor.

For mice on a high fructose diet, they found that when they increased the availability of food from 9, to 12, to 15 hours a day, the percentage of fat mass increased in a linear fashion. The longer the mice had to eat their allotted food, the fatter they became.

The journal Nutrition Reviews presented an article Time-restricted feeding and risk of metabolic disease: a review of human and animal studies. This article indicated that animal studies of time restricted feeding have shown “reductions in body weight, total cholesterol, and concentrations of triglycerides, glucose, insulin, interleukin, and tumor necrosis factor-α as well as with improvements in insulin sensitivity.” They go on to indicate that human studies confirm these results.

Time restricted eating may just be the key you are looking for in your weight loss journey. After all, the longer your body goes without consuming sugars, the longer your body will be forced to burn fat. And, that’s what will provide long lasting health to an overweight generation.

Time-Restricted Eating May Reverse Diabetes & Obesity

Prof. Satchin Panda, Amandine Chaix, and Amir Zarrinpar of the Regulatory Biology Laboratory at the Salk Institute explain their discovery that time-restricted eating shows signs of reversing the effects of obesity and diabetes in mice. For more info: http://www.salk.edu/news/pressrelease_details.php?press_id=2062
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